Ferroptosis in Leukemia: Lessons and Challenges

Ferroptosis is a newly defined programmed cell death (PCD) process with the hallmark of accumulation iron-dependent lipid peroxidation, which more immunogenic over apoptosis. shows great potential as therapeutic target against acute kidney injury (AKI), cancers, cardiovascular diseases, neurodegenerative and hepatic diseases. Accumulating evidence has highlighted that ferroptosis plays an unneglectable role in regulating development progression multiple pathologies leukemia including myeloid (AML), chronic (CML), lymphoblastic (ALL), lymphocytic (CLL). Herein, we focus on state-of-the-art renewal relationship leukemia. Meanwhile, this chapter further highlights iron, amino acid metabolism, well ferroptosis-based molecular mechanisms. Collectively, summarize contribution to pathogenesis discuss novel for different types